The tocotrienol fraction, gamma-tocotrienol is known to possess anti-cancer properties buts its various mechanisms of action have as of yet, not been fully defined. In breast cancer cell lines, the gamma portion of the tocotrienol fraction of the vitamin E complex was shown to induce cancer cell apoptosis through a variety of mechanisms that include induction of Nrf-2 oxidative stress response and activation of pathways that increase the endoplasmic reticulum stress response leading to cell apoptosis.
Source: Designs for Health, Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells
By: Dr. Noble
It was exciting to me when my daughter came home with an article titled “Dying to Look Good,” in the October 8th, 2012 issue of Science World magazine. It is about young Ava, who is spreading awareness of the health concern of skin products and creating her own line of chemical free products. Your skin is the largest organ in the body. The products that you are putting on it can get absorbed into the skin. They can disrupt your hormones increasing risk for hormone related problems and cancers.
We use about a dozen different products on our skin a day. More and more research is being done on the effects of the chemicals they contain on our health. Some substances to be cautious of are phthalates or fragrances, parabens, polyethylene glycol (PEG), retinyl palmitate (Vitamin A), Petrolatum, sodium laureth sulfate, and Triclosan. The retinols (Vitamin A) can possibly even cause genetic malformations in the growing fetus. If you are looking for the skin enhancing effect; Retinaldehyde, the storage product, is much better choice. It can be broken down naturally to retinoic acid by the body as it is needed still creating more collagen and elastin. Other products like Ava Anderson and Noble Natural are out there. You just have to do your research. You can evaluate your products through the environmental workers group Skin Deep Database.
But do not forget that the most important place to start with beautifying your skin, is through a healthy diet and clean living. Improving gut health, proper nutrition, detoxification, stress reduction, sleep and hydration are the key to not just looking good; But feeling great too.
By: Dr. Noble
It has been estimated that Breast Cancer affects 70 million women today. One in 8 or more are being diagnosed yearly. The treatment can be disfiguring surgery, illness provoking chemotherapy, uncomfortable radiation and hormone inhibition. It is disappointing to me that there is so much focus on treatment and less on prevention these days. It seems to take so many years to change our thinking. Do we have to continue to wait for every double blind, placebo controlled study with 16,000 or more enrolled patients to be published before we can offer our patients a better alternative?
If you knew of a simple way to lower your risk of breast cancer, wouldn’t you want your daughter, mother, sister or best friend to do it? I know I would. Yes, we do not know enough about everything that causes breast cancer. But we do know that there are some simple ways to know your risk and then take steps to reduce it.
For instance, we have 3 different types of estrogens: Estriol (E3), Estradiol (E2)and Estrone (E1). Once you go through menopause, your adrenal glands make E1. Both estradiol (E2) and Estrone (E1) have cancer producing effects; Whereas, their breakdown product, Estriol (E3) has been shown to have some protective effects or no risk. E3 is mainly produced during pregnancy or is affected by your diet. You can test the balance between these estrogens, the Estrogen Quotient (EQ), thru a 24 hour urine study done on day 19 to 23 of your cycle if you are still menstruating. Getting this EQ higher than 1 can help you lower your risk.
In addition, making sure your cancer producing Estrone is broken down along the right pathway can also help with reduction in risk. Estrone is produced by your adrenal glands after your ovaries fail in menopause and from adipose/fat cells. It can be broken down to 2, 4 or 16 hydroxyestrogen. We want more of the 2 and less of the 16. Therefore, we can again do this 24 hour urine study and find the ratio of 2/16. Keeping it greater than 1 is the key to lower risk.
In addition, ensuring that the enzyme, catechol-O-methyltransferase (COMT) can detoxify these estrogens is essential. Making sure you have adequate B vitamins, B12, folic acid, certain amino acids and eating enough vegetable from the brassica plant family can all assist in the process of increasing your ratios and detoxification abilities. If these don’t do the trick after 3-4 months of therapy, you can take dindolylmethane (Noble DIM) or indole-3-carbinol (I3C). If still unresponsive, we can even test how well this enzyme is functioning thru genetic testing. So even though we do not know everything about why breast cancer occurs, Let’s change the focus to prevention!